Kalju Kahn) website for Fall 2009ĭrug Design 162B (by Dr. (No Password Needed) Warning: Large Fileĭrug Design 162A (by Dr. Silverman (Second Edition)Īn Introduction to Medicinal Chemistry (Fourth Edition) The Organic Chemistry of Drug Design and Drug Action by Richard B. Lecture: MWF 8:00-8:50 Place: Phelps 1508Ĭomputer Lab: Open day access Place: Chem 1153 Students are allowed to take Chem 162B/262B without taking Chem 162A/262B this academic year. Finally, issues of pharmacokinetics and drug metabolism will be dealt with. Chem 162B will also cover approaches used to design competitive and mechanism-based inhibitors based on the mechanistic understanding of enzyme catalysis. It will outline experimental and computational methods for the study of ligand-protein complexes, and discuss how the knowledge of the three-dimensional structure of the active site helps in the lead optimization process. The latter course focuses on structure-based drug design. The second course in the series, Chem 162B, will be taught in the Spring of 2012. We will cover membrane-bound ion-channels and receptor proteins, and discuss strategies for finding agonists and antagonists for these types of targets. Topics covered include target identification and validation technologies, generation and screening of chemical libraries for finding lead compounds, and modern medicinal chemistry approaches for ligand-based lead optimization. About Chem 162AĬhem 162A, the first in the two-course series focuses on principles of rational drug design. Students in the course follow a path similar to that taken by real-life drug developers by learning important elements of the drug design process in a logical order. To teach principles that govern the process of modern drug discovery and development. Office hours: Mon 10:30-11:30 PM, and Tue 4:30-5:30 PMĮ-mail: Teaching Assistant Mission statement
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